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Human Clinical Research Human studies have examined Epithalon effects on various biomarkers of aging

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There are four principal drivers of this progress: Client demand: Growing demands from beneficiaries and clients for greater transparency about how their money is invested Regulation: More guidance from regulators that considering ESG factors is part of an investors fiduciary duty Sustainability outcomes: Growing interest from investors and other stakeholders in examining how investment decisions affect real-world outcomes Materiality: Increasing recognition that certain ESG factors can affect risk and return ESG integration in listed equity: A five-part process The PRI defines ESG integration as the process of including ESG factors in investment analysis and decisions to better manage risks and improve returns

Ethics declarations Competing interests DJC has received investigator-initiated grants from Astra Zeneca and Novo Nordisk, as well as speaker fees for lectures